List of matches in this round
- TimeMatch
- September 4, 2021
- 3:00 pmHarrogate Pythons RUFC 1st XV23:15Bramley Phoenix RFC
- September 11, 2021
- 3:00 pmBurley RUFC0-38Harrogate Pythons RUFC 1st XV
- September 18, 2021
- 3:00 pmHarrogate Pythons RUFC 1st XV18:45Barnsley RUFC
- September 25, 2021
- 3:00 pmKnottingley RUFC32:17Harrogate Pythons RUFC 1st XV
- October 2, 2021
- 3:00 pmHarrogate Pythons RUFC 1st XV11:6West Park Leeds RUFC
- October 16, 2021
- 3:00 pmHarrogate Pythons RUFC 1st XV25:0Old Otliensians RUFC
- October 23, 2021
- 3:00 pmWibsey RUFC23:31Harrogate Pythons RUFC 1st XV
- October 30, 2021
- 3:00 pmHarrogate Pythons RUFC 1st XV31:10Ossett RUFC
- November 6, 2021
- 2:15 pmMarist RUFCTo be RescheduledHarrogate Pythons RUFC 1st XV
- November 13, 2021
- 2:15 pmCastleford RUFC12:10Harrogate Pythons RUFC 1st XV
- November 20, 2021
- 2:15 pmHarrogate Pythons RUFC 1st XV34:19Halifax Vandals RUFC
- December 4, 2021
- 2:15 pmHarrogate Pythons RUFC 1st XV62:7Hemsworth RUFC
- December 11, 2021
- 2:15 pmSkipton RFC0:35Harrogate Pythons RUFC 1st XV
- January 8, 2022
- 2:15 pmBarnsley RUFC0:18Harrogate Pythons RUFC 1st XV
- January 15, 2022
- 2:15 pmHarrogate Pythons RUFC 1st XV25:0Knottingley RUFC
- January 22, 2022
- 2:15 pmWest Park Leeds RUFC12:54Harrogate Pythons RUFC 1st XV
- January 29, 2022
- 2:15 pmOld Otliensians RUFC0:105Harrogate Pythons RUFC 1st XV
- February 5, 2022
- 2:15 pmSheffield Medicals RUFC5:50Harrogate Pythons RUFC 1st XV
- February 12, 2022
- 2:15 pmHarrogate Pythons RUFC 1st XV53:0Wibsey RUFC
- February 26, 2022
- 2:15 pmHarrogate Pythons RUFC 1st XV55:10Burley RUFC
- March 5, 2022
- 3:00 pmHarrogate Pythons RUFC 1st XV49:19Castleford RUFC
- March 12, 2022
- 3:00 pmHalifax Vandals RUFC8:24Harrogate Pythons RUFC 1st XV
- March 19, 2022
- 3:00 pmOssett RUFC0:67Harrogate Pythons RUFC 1st XV
- March 26, 2022
- 3:00 pmHarrogate Pythons RUFC 1st XV62:21Sheffield Medicals RUFC
- April 2, 2022
- 3:00 pmHemsworth RUFC12:40Harrogate Pythons RUFC 1st XV
- April 9, 2022
- 3:00 pmHarrogate Pythons RUFC 1st XV50:0Skipton RFC
- April 23, 2022
- 3:00 pmBramley Phoenix RFC19:42Harrogate Pythons RUFC 1st XV